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    Evaludating com

    Evaluation is a systematic determination of a subject's merit, worth and significance, using criteria governed by a set of standards.It can assist an organization, program, project or any other intervention or initiative to assess any aim, realisable concept/proposal, or any alternative, to help in decision-making; or to ascertain the degree of achievement or value in regard to the aim and objectives and results of any such action that has been completed.FDA granted orphan drug designation to PEGPH20 for treatment of pancreas cancer and fast track designation for PEGPH20 in combination with gemcitabine and nab-paclitaxel for the treatment of metastatic pancreas cancer.Additionally, the European Commission, acting on the recommendation from the Committee for Orphan Medicinal Products of the European Medicines Agency, designated investigational drug PEGPH20 an orphan medicinal product for the treatment of pancreas cancer.We review methods and conditions sufficient for accurate estimation within the proposed framework.

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    The Phase 1b/2, open-label, multicenter, randomized clinical trial is designed to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of immunotherapy-based treatment combinations compared with the standard chemotherapy regimens.Reducing human immunodeficiency virus (HIV) racial/ethnic disparities is a high priority.Reductions in HIV racial/ethnic disparities can potentially be achieved by intervening on important intermediates.We describe a useful conceptual and methodological framework for appropriately evaluating the impact of interventions to reduce HIV racial/ethnic disparities using observational data.This framework reframes relevant scientific questions in terms of a controlled direct effect and estimates a corresponding proportion eliminated.

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